Differential <i>In Vitro</i> Activities of Individual Drugs and Bedaquiline-Rifabutin Combinations against Actively Multiplying and Nutrient-Starved Mycobacterium abscessus
نویسندگان
چکیده
Current treatment options for lung disease caused by Mycobacterium abscessus complex infections have limited effectiveness. To maximize the use of existing antibacterials and to help inform regimen design treatment, we assessed in vitro bactericidal activity single drugs against actively multiplying net nonreplicating M. populations nutrient-rich nutrient-starvation conditions, respectively. As drugs, bedaquiline rifabutin exerted only nutrient-starved growing ,
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2021
ISSN: ['0066-4804', '1070-6283', '1098-6596']
DOI: https://doi.org/10.1128/aac.02179-20